• Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin 

      Kostovski, Emil; Dahm, Anders Erik A; Mowinckel, Marie-Christine; Stranda, Annicke; Skretting, Grethe; Østerud, Bjarne; Sandset, Per Morten; Iversen, Per Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-03)
      Study design: This is a double-blind, randomized, placebo-controlled cross-over study of melatonin in complete tetraplegia.<p> <p>Objectives: Tetraplegic patients have an increased risk of venous thrombosis despite prophylaxis, blunted variations in melatonin and altered circadian variation of several hemostatic markers. To examine whether melatonin could modify the regulation of hemostasis, we ...
    • Elevated complement C3 and C4 levels are associated with postnatal pregnancy-related venous thrombosis 

      Dahm, Anders Erik A; Jacobsen, Eva-Marie; Wik, Hilde Skuterud; Jacobsen, Anne Flem; Mollnes, Tom Eirik; Kanse, Sandip; Sandset, Per Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-29)
      High levels of complement C3 are associated with venous thrombosis (VT) in the general population. We investigated if high C3 and C4 levels were associated with pregnancy-related VT. We undertook the Norwegian VIP study, a case–control study of VT in pregnancy or within 3 months postpartum (cases, n = 313) and women without pregnancy-related VT (controls, <i>n</i> = 353). Determinants of C3 and C4 ...
    • Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation 

      Kostovski, Emil; Frigato, E; Savikj, Mladen; Dahm, Anders Erik A; Sandset, Per Morten; Mowinckel, Marie-Christine; Skretting, Grethe; Østerud, Bjarne; Bertolucci, C; Iversen, Per Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-09)
      <i>Study design</i>: Crossover double blind, randomized placebo-controlled trial.<p> <p><i>Objectives</i>: Circadian oscillators are located both in the brain and in peripheral organs. Melatonin, the main brain-derived hormone governing circadian variations, is highly associated with daylight patterns. However, in subjects with tetraplegia the melatonin levels are blunted. Here we studied peripheral ...